The race to develop safe and effective SARS-COV-2 vaccines has moved with unprecedented speed.There are now multiple vaccines that have received emergency Heritage Dish use authorization from the United States Food and Drug Administration and a host of candidates positioned for approval worldwide.Attention has now turned to allocation, distribution
GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
Summary: Molecular mechanisms mediating cardiac hypertrophy by glucose metabolism are incompletely understood.Hexosamine biosynthesis axe pathway (HBP), an accessory pathway of glycolysis, is known to be involved in the attachment of O-linked N-acetylglucosamine motif (O-GlcNAcylation) to proteins, a post-translational modification.We here demonstr
Temperature-derived potential for the establishment of phlebotomine sandflies and visceral leishmaniasis in Germany
Climate change is expected to manifest in the shift of organisms to regions where they were not present in the past, potentially entailing previously unseen biological risks.However, studies evaluating these future trends are scarce.Here, an important group of vectors (sandflies) and the pathogen transmitted (Leishmania infantum complex) causing th
Effects of alkaline biocides on enterococcus faecalis - An in vitro study
The purpose of this study was to do a comparative microbial assessment of disinfecting potential of Calcium hydroxide and Bioactive glass against Enterococcus faecalis when used as an intracanal medicament.Thirty single rooted premolars undergoing extraction for orthodontic treatment were selected.Root canals of teeth with fully formed apices were